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<article article-type="review-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">sibneiro</journal-id><journal-title-group><journal-title xml:lang="ru">Сибнейро</journal-title><trans-title-group xml:lang="en"><trans-title>Sibneuro</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">3033-649X</issn><issn pub-type="epub">3033-6805</issn><publisher><publisher-name>Bervitskiy Anatoliy Vladimirovich</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.64265/3033-649X-2026.2.1.12-23</article-id><article-id custom-type="elpub" pub-id-type="custom">sibneiro-58</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Лекция</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Lecture</subject></subj-group></article-categories><title-group><article-title>Возможности магнитно-резонансной диагностики идиопатической нормотензивной гидроцефалии. Обзор научной литературы</article-title><trans-title-group xml:lang="en"><trans-title>Magnetic resonance imaging for idiopathic normal-pressure hydrocephalus: A review of the scientific literature</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8880-100X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Богомякова</surname><given-names>О. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Bogomyakova</surname><given-names>O. B.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Богомякова Ольга Борисовна – доктор медицинских наук, врач-рентгенолог, научный сотрудник; старший преподаватель</p><p>ул. Институтская, д. 3а, г. Новосибирск, 630090</p><p>ул. Пирогова, д. 1, г. Новосибирск, 630090</p></bio><bio xml:lang="en"><p>Olga B. Bogomyakova – Dr. Sci. (Med.), Radiologist, Research Officer</p><p>Institutskaya str., 3A, Novosibirsk, 630090</p><p>Pirogova str., 1, Novosibirsk, 630090</p></bio><email xlink:type="simple">bogom_o@tomo.nsc.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7959-5160</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Станкевич</surname><given-names>Ю. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Stankevich</surname><given-names>Yu. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Станкевич Юлия Александровна – кандидат медицинских наук, врач-рентгенолог, старший научный сотрудник; старший преподаватель</p><p>ул. Институтская, д. 3а, г. Новосибирск, 630090</p><p>ул. Пирогова, д. 1, г. Новосибирск, 630090</p></bio><bio xml:lang="en"><p>Yuliya A. Stankevich – Cand. Sci. (Med.), Radiologist, Senior Research Officer</p><p>Institutskaya str., 3A, Novosibirsk, 630090</p><p>Pirogova str., 1, Novosibirsk, 630090</p></bio><email xlink:type="simple">stankevich@tomo.nsc.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1277-4113</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Тулупов</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Tulupov</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Тулупов Андрей Александрович– доктор медицинских наук, профессор, член-корреспондент РАН, главный научный сотрудник; заместитель директора Центра постдипломного медицинского образования ИММТ</p><p>ул. Институтская, д. 3а, г. Новосибирск, 630090</p><p>ул. Пирогова, д. 1, г. Новосибирск, 630090</p></bio><bio xml:lang="en"><p>Andrey A. Tulupov – Dr. Sci. (Med.), Professor, Corresponding Member of the RAS, Chief Research Officer; Deputy Head of the Center for Postgraduate Medical Education</p><p>Institutskaya str., 3A, Novosibirsk, 630090</p><p>Pirogova str., 1, Novosibirsk, 630090</p><p> </p></bio><email xlink:type="simple">taa@tomo.nsc.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">Международный томографический центр СО РАН; Новосибирский национальный исследовательский государственный университет<country>Россия</country></aff><aff xml:lang="en">The Institute International Tomography Center of the Siberian Branch of the Russian Academy of Sciences; Novosibirsk State University<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2026</year></pub-date><pub-date pub-type="epub"><day>27</day><month>03</month><year>2026</year></pub-date><volume>2</volume><issue>1</issue><fpage>12</fpage><lpage>23</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Богомякова О.Б., Станкевич Ю.А., Тулупов А.А., 2026</copyright-statement><copyright-year>2026</copyright-year><copyright-holder xml:lang="ru">Богомякова О.Б., Станкевич Ю.А., Тулупов А.А.</copyright-holder><copyright-holder xml:lang="en">Bogomyakova O.B., Stankevich Y.A., Tulupov A.A.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.sibneurojournal.com/jour/article/view/58">https://www.sibneurojournal.com/jour/article/view/58</self-uri><abstract><p>Среди пожилых пациентов социально значимой и пока нерешенной проблемой современной медицины является нормотензивная гидроцефалия (НТГ), диагностика которой существенно осложняется схожестью клинических проявлений с нейродегенеративными и сосудистыми заболеваниями (сосудистая деменция, болезнь Альцгеймера, прогрессирующий надъядерный паралич).</p><p>Цель обзора. Представить нейрорадиологические маркеры, обычно ассоциирующиеся снормотензивной гидроцефалией, а также современную шкалу оценки вероятности НТГ (Radscale), ее преимущества и недостатки. Данная шкала позволяет стандартизовать оценку радиологических признаков при подозрении на НТГ и может использоваться в качестве диагностического скринингового инструмента.</p></abstract><trans-abstract xml:lang="en"><p>Among elderly patients, normal pressure hydrocephalus (NPH) is a socially significant and as yet unresolved problem in modern medicine. Its diagnosis is signifi cantly complicated by the similarity of its clinical manifestations to those of neurodegenerative and vascular diseases (vascular dementia, Alzheimer’s disease, progressive supranuclear palsy).</p><p>The aim. To present the neuroradiological markers commonly associated with normal pressure hydrocephalus, as well as the current radiological scale for assessing the probability of NPH (Radscale), its advantages, and disadvantages. This scale allows for the standardization of the assessment of radiological signs when NPH is suspected and can be used as a diagnostic screening tool.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>центральная нервная система</kwd><kwd>цереброспинальная жидкость</kwd><kwd>нормотензивная гидроцефалия</kwd><kwd>магнитно-резонансная томография</kwd></kwd-group><kwd-group xml:lang="en"><kwd>central nervous system</kwd><kwd>cerebrospinal fluid</kwd><kwd>normal pressure hydrocephalus</kwd><kwd>magnetic resonance imaging</kwd></kwd-group><funding-group xml:lang="ru"><funding-statement>Мы благодарим Министерство науки и высшего образования Российской Федерации задоступ кМРТ-оборудованию.</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Agarwal A, Bathla G, Kanekar S. Imaging of communicating hydrocephalus. Semin Ultrasound CT MRI. 2016; 37(2): 100-108. https://doi.org/10.1053/j.sult.2016.02.007</mixed-citation><mixed-citation xml:lang="en">Agarwal A, Bathla G, Kanekar S. Imaging of communicating hydrocephalus. Semin Ultrasound CT MRI. 2016; 37(2): 100-108. https://doi.org/10.1053/j.sult.2016.02.007</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Solanki K, Singh J, Gupta T. Role of MRI in evaluation of hydrocephalus. Eur Chem Bull. 2023; 12: 1175-1183.</mixed-citation><mixed-citation xml:lang="en">Solanki K, Singh J, Gupta T. Role of MRI in evaluation of hydrocephalus. Eur Chem Bull. 2023; 12: 1175-1183.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Bouzerar R, Ambarki K, Balédent O, Kongolo G, Picot JC, Meyer ME. Ventricular dilation as an instability of intracranial dynamics. Physical Rewiew E. 2005; 72(5 Pt 1):051912. https://doi.org/10.1103/PhysRevE.72.051912</mixed-citation><mixed-citation xml:lang="en">Bouzerar R, Ambarki K, Balédent O, Kongolo G, Picot JC, Meyer ME. Ventricular dilation as an instability of intracranial dynamics. Physical Rewiew E. 2005; 72(5 Pt 1):051912. https://doi.org/10.1103/PhysRevE.72.051912</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Martín-Láez R, Caballero-Arzapalo H, López-Menéndez LÁ, Arango-Lasprilla JC, Vázquez-Barquero A. Epidemiology of idiopathic normal pressure hydrocephalus: A systematic review of the literature. World Neurosurg. 2015; 84(6): 2002-2009. https://doi.org/10.1016/j.wneu.2015.07.005</mixed-citation><mixed-citation xml:lang="en">Martín-Láez R, Caballero-Arzapalo H, López-Menéndez LÁ, Arango-Lasprilla JC, Vázquez-Barquero A. Epidemiology of idiopathic normal pressure hydrocephalus: A systematic review of the literature. World Neurosurg. 2015; 84(6): 2002-2009. https://doi.org/10.1016/j.wneu.2015.07.005</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Grahnke K, Jusue-Torres I, Szujewski C, Joyce C, Schneck M, Prabhu VC, et al. The quest for predicting sustained shunt response in normal-pressure hydrocephalus: An analysis of the callosal angle’s utility. World Neurosurg. 2018; 115: e717-e722. https://doi.org/10.1016/j.wneu.2018.04.150</mixed-citation><mixed-citation xml:lang="en">Grahnke K, Jusue-Torres I, Szujewski C, Joyce C, Schneck M, Prabhu VC, et al. The quest for predicting sustained shunt response in normal-pressure hydrocephalus: An analysis of the callosal angle’s utility. World Neurosurg. 2018; 115: e717-e722. https://doi.org/10.1016/j.wneu.2018.04.150</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Klassen BT, Ahlskog JE. Normal pressure hydrocephalus: How often does the diagnosis hold water? Neurology. 2011; 77(12): 1119-1125. https://doi.org/10.1212/WNL.0b013e31822f02f5</mixed-citation><mixed-citation xml:lang="en">Klassen BT, Ahlskog JE. Normal pressure hydrocephalus: How often does the diagnosis hold water? Neurology. 2011; 77(12): 1119-1125. https://doi.org/10.1212/WNL.0b013e31822f02f5</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Lemcke J, Stengel D, Stockhammer F, Güthoff C, Rohde V, Meier U. Nationwide incidence of normal pressure hydrocephalus (NPH) assessed by insurance claim data in Germany. Open Neurol J. 2016; 10: 15-24. https://doi.org/10.2174/1874205X01610010015</mixed-citation><mixed-citation xml:lang="en">Lemcke J, Stengel D, Stockhammer F, Güthoff C, Rohde V, Meier U. Nationwide incidence of normal pressure hydrocephalus (NPH) assessed by insurance claim data in Germany. Open Neurol J. 2016; 10: 15-24. https://doi.org/10.2174/1874205X01610010015</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Das JM, Biagioni MC. Normal pressure hydrocephalus. Treasure Island (FL): StatPearls Publishing; 2025.</mixed-citation><mixed-citation xml:lang="en">Das JM, Biagioni MC. Normal pressure hydrocephalus. Treasure Island (FL): StatPearls Publishing; 2025.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Williams H. A unifying hypothesis for hydrocephalus and the Chiari malformations part two: The hydrocephalus fi lling mechanism. Med Hypotheses. 2016; 94: 30-39. https://doi.org/10.1016/j.mehy.2016.06.013</mixed-citation><mixed-citation xml:lang="en">Williams H. A unifying hypothesis for hydrocephalus and the Chiari malformations part two: The hydrocephalus fi lling mechanism. Med Hypotheses. 2016; 94: 30-39. https://doi.org/10.1016/j.mehy.2016.06.013</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Oliveira LM, Nitrini R, Román GC. Normal-pressure hydrocephalus: A critical review. Dement Neuropsychol. 2019; 13(2): 133-143. https://doi.org/10.1590/1980-57642018dn13-020001</mixed-citation><mixed-citation xml:lang="en">Oliveira LM, Nitrini R, Román GC. Normal-pressure hydrocephalus: A critical review. Dement Neuropsychol. 2019; 13(2): 133-143. https://doi.org/10.1590/1980-57642018dn13-020001</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Nikaido Y, Urakami H, Akisue T, Okada Y, Katsuta N, Kawami Y, et al. Associations among falls, gait variability, and balance function in idiopathic normal pressure hydrocephalus. Clin Neurol Neurosurg. 2019; 183: 105385. https://doi.org/10.1016/j.clineuro.2019.105385</mixed-citation><mixed-citation xml:lang="en">Nikaido Y, Urakami H, Akisue T, Okada Y, Katsuta N, Kawami Y, et al. Associations among falls, gait variability, and balance function in idiopathic normal pressure hydrocephalus. Clin Neurol Neurosurg. 2019; 183: 105385. https://doi.org/10.1016/j.clineuro.2019.105385</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Yamada S, Mase M. Cerebrospinal fl uid production and absorption and ventricular enlargement mechanisms in hydrocephalus. Neurol Med Chir (Tokyo). 2023; 63(4): 141-151. https://doi.org/10.2176/jns-nmc.2022-0331</mixed-citation><mixed-citation xml:lang="en">Yamada S, Mase M. Cerebrospinal fl uid production and absorption and ventricular enlargement mechanisms in hydrocephalus. Neurol Med Chir (Tokyo). 2023; 63(4): 141-151. https://doi.org/10.2176/jns-nmc.2022-0331</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Hakim S, Venegas JG, Burton JD. The physics of the cranial cavity, hydrocephalus and normal pressure hydrocephalus: Mechanical interpretation and mathematical model. Surg Neurol. 1976; 5(3): 187-210.</mixed-citation><mixed-citation xml:lang="en">Hakim S, Venegas JG, Burton JD. The physics of the cranial cavity, hydrocephalus and normal pressure hydrocephalus: Mechanical interpretation and mathematical model. Surg Neurol. 1976; 5(3): 187-210.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Bradley WG. Normal pressure hydrocephalus: New concepts on etiology and diagnosis. AJNR Am J Neuroradiol. 2000; 21(9): 1586-1590.</mixed-citation><mixed-citation xml:lang="en">Bradley WG. Normal pressure hydrocephalus: New concepts on etiology and diagnosis. AJNR Am J Neuroradiol. 2000; 21(9): 1586-1590.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Nakajima M, Yamada S, Miyajima M, Ishii K, Kuriyama N, Kazui H, et al.; Research Committee of Idiopathic Normal Pressure Hydrocephalus. Guidelines for management of idiopathic normal pressure hydrocephalus (Third Edition): Endorsed by the Japanese Society of Normal Pressure Hydrocephalus. Neurol Med Chir (Tokyo). 2021; 61(2): 63-97. https://doi.org/10.2176/nmc.st.2020-0292</mixed-citation><mixed-citation xml:lang="en">Nakajima M, Yamada S, Miyajima M, Ishii K, Kuriyama N, Kazui H, et al.; Research Committee of Idiopathic Normal Pressure Hydrocephalus. Guidelines for management of idiopathic normal pressure hydrocephalus (Third Edition): Endorsed by the Japanese Society of Normal Pressure Hydrocephalus. Neurol Med Chir (Tokyo). 2021; 61(2): 63-97. https://doi.org/10.2176/nmc.st.2020-0292</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Greenberg ABW, Mehta NH, Mekbib KY, Kiziltug E, Smith HR, Hyman BT, et al. Cases of familial idiopathic normal pressure hydrocephalus implicate genetic factors in disease pathogenesis. Cereb Cortex. 2023; 33(23): 11400-11407. https://doi.org/10.1093/cercor/bhad374</mixed-citation><mixed-citation xml:lang="en">Greenberg ABW, Mehta NH, Mekbib KY, Kiziltug E, Smith HR, Hyman BT, et al. Cases of familial idiopathic normal pressure hydrocephalus implicate genetic factors in disease pathogenesis. Cereb Cortex. 2023; 33(23): 11400-11407. https://doi.org/10.1093/cercor/bhad374</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Relkin NR. Is normal pressure hydrocephalus a complex genetic disorder? Neurology. 2024; 103(5): e209784. https://doi.org/10.1212/WNL.0000000000209784</mixed-citation><mixed-citation xml:lang="en">Relkin NR. Is normal pressure hydrocephalus a complex genetic disorder? Neurology. 2024; 103(5): e209784. https://doi.org/10.1212/WNL.0000000000209784</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Ghosh S, Lippa C. Diagnosis and prognosis in idiopathic normal pressure hydrocephalus. Am J Alzheimers Dis Other Demen. 2014; 29(7): 583-589. https://doi.org/10.1177/1533317514523485</mixed-citation><mixed-citation xml:lang="en">Ghosh S, Lippa C. Diagnosis and prognosis in idiopathic normal pressure hydrocephalus. Am J Alzheimers Dis Other Demen. 2014; 29(7): 583-589. https://doi.org/10.1177/1533317514523485</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Bradley WG Jr. Magnetic resonance imaging of normal pressure hydrocephalus. Semin Ultrasound CT MR. 2016; 37(2): 120-128. https://doi.org/10.1053/j.sult.2016.01.005</mixed-citation><mixed-citation xml:lang="en">Bradley WG Jr. Magnetic resonance imaging of normal pressure hydrocephalus. Semin Ultrasound CT MR. 2016; 37(2): 120-128. https://doi.org/10.1053/j.sult.2016.01.005</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Keong NC, Pena A, Price SJ, Czosnyka M, Czosnyka Z, Pickard JD. Imaging normal pressure hydrocephalus: Theories, techniques, and challenges. Neurosurg Focus. 2016; 41(3): E11. https://doi.org/10.3171/2016.7.FOCUS16194</mixed-citation><mixed-citation xml:lang="en">Keong NC, Pena A, Price SJ, Czosnyka M, Czosnyka Z, Pickard JD. Imaging normal pressure hydrocephalus: Theories, techniques, and challenges. Neurosurg Focus. 2016; 41(3): E11. https://doi.org/10.3171/2016.7.FOCUS16194</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Yin LK, Zheng JJ, Zhao L, Hao XZ, Zhang XX, Tian JQ, et al. Reversed aqueductal cerebrospinal fl uid net fl ow in idiopathic normal pressure hydrocephalus. Acta Neurol Scand. 2017; 136(5): 434-439. https://doi.org/10.1111/ane.12750</mixed-citation><mixed-citation xml:lang="en">Yin LK, Zheng JJ, Zhao L, Hao XZ, Zhang XX, Tian JQ, et al. Reversed aqueductal cerebrospinal fl uid net fl ow in idiopathic normal pressure hydrocephalus. Acta Neurol Scand. 2017; 136(5): 434-439. https://doi.org/10.1111/ane.12750</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Andersson J, Rosell M, Kockum K, Söderström L, Laurell K. Challenges in diagnosing normal pressure hydrocephalus: Evaluation of the diagnostic guidelines. eNeurological Sci. 2017; 7: 27-31. https://doi.org/10.1016/j.ensci.2017.04.002</mixed-citation><mixed-citation xml:lang="en">Andersson J, Rosell M, Kockum K, Söderström L, Laurell K. Challenges in diagnosing normal pressure hydrocephalus: Evaluation of the diagnostic guidelines. eNeurological Sci. 2017; 7: 27-31. https://doi.org/10.1016/j.ensci.2017.04.002</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">ЛобзинВЮ, АлизадеМР, ЛапинаАВ, ЛобзинСВ, КолмаковаКА, ГавриловГВ, идр. Идиопатическая нормотензивная гидроцефалия иболезнь Альцгеймера вклинической практике: коморбидность идифференциация. Медицинский алфавит. 2020; (22): 36-43. https://doi.org/10.33667/2078-5631-202022-36-43</mixed-citation><mixed-citation xml:lang="en">Lobzin VYu, Alizade MR, Lapina AV, Lobzin SV, Kolmakova KA, Gavrilov GV, et al. Idiopathic normal pressure hydrocephalus and Alzheimer’s disease in clinical practice: comorbidity and diff erentiation. Medical Alphabet. 2020; (22): 36-43. (In Russ.)]. https://doi.org/10.33667/2078-5631-202022-36-43</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Tipton PW, Elder BD, Cogswell PM, Graff -Radford N. Normal pressure hydrocephalus, or Hakim syndrome: Review and update. Neurol Neurochir Pol. 2024; 58(1): 8-20. https://doi.org/10.5603/pjnns.97343</mixed-citation><mixed-citation xml:lang="en">Tipton PW, Elder BD, Cogswell PM, Graff -Radford N. Normal pressure hydrocephalus, or Hakim syndrome: Review and update. Neurol Neurochir Pol. 2024; 58(1): 8-20. https://doi.org/10.5603/pjnns.97343</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">КротенковаМВ, КремневаЕИ, АхметзяновБМ, ДобрынинаЛА. Изменение венозного кровотока привозраст-зависимой церебральной микроангиопатии поданным магнитно-резонансной томографии. REJR. 2020; 10(2): 61-70. https://doi.org/10.21569/2222-7415-2020-10-2-61-70</mixed-citation><mixed-citation xml:lang="en">Krotenkova MV, Kremneva EI, Akhmetzyanov BM, Dobrynina LA. Venous blood fl ow changes in age-related cerebral small vessel disease as assessed by MRI. REJR. 2020; 10(2): 61-70. (In Russ.)]. https://doi.org/10.21569/2222-7415-2020-10-2-61-70</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">МенделевичЕГ. Нормотензивная гидроцефалия ицеребральная амилоидная ангиопатия: комбинация заболеваний илиединство патогенеза? Неврология, нейропсихиатрия, психосоматика. 2020; 12(6): 104-109. https://doi.org/10.14412/2074-2711-20206-104-109</mixed-citation><mixed-citation xml:lang="en">Mendelevich EG. Normal pressure hydrocephalus and cerebral amyloid angiopathy: A set of diseases or the unity of pathogenesis? Neurology, Neuropsychiatry, Psychosomatics. 2020; 12(6): 104-109. (In Russ.)]. https://doi.org/10.14412/2074-2711-20206-104-109</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">ГавриловГВ, СтанишевскийАВ, ГайдарБВ, СвистовДВ. Идиопатическая нормотензивная гидроцефалия. Ретроспектива гипотез патогенеза исовременные теории. Патологическая физиология иэкспериментальная терапия. 2020; 64(3): 146-155. https://doi.org/10.25557/0031-2991.2020.03.146-155</mixed-citation><mixed-citation xml:lang="en">Gavrilov GV, Stanishevsky AV, Gaidar BV, Svistov DV. Idiopathic normal pressure hydrocephalus. Retrospective review of pathogenesis and modern theories. Pathological Physiology and Experimental Therapy. 2020; 64(3): 146-155. (In Russ.)]. https://doi.org/10.25557/0031-2991.2020.03.146-155</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">de Guilhem de Lataillade A, Boutoleau-Bretonnière C, Aguilar-Garcia J, Pallardy A, Bigot-Corbel E, Roualdes V, et al. Idiopathic normal pressure hydrocephalus and frontotemporal dementia: An unexpected association. Brain Commun. 2022; 4(6): fcac319. https://doi.org/10.1093/braincomms/fcac319</mixed-citation><mixed-citation xml:lang="en">de Guilhem de Lataillade A, Boutoleau-Bretonnière C, Aguilar-Garcia J, Pallardy A, Bigot-Corbel E, Roualdes V, et al. Idiopathic normal pressure hydrocephalus and frontotemporal dementia: An unexpected association. Brain Commun. 2022; 4(6): fcac319. https://doi.org/10.1093/braincomms/fcac319</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Stoquart-ElSankari S, Balédent O, Gondry-Jouet C, Makki M, Godefroy O, Meyer ME. Aging eff ects on cerebral blood and cerebrospinal fl uid fl ows. J Cereb Blood Flow Metab. 2007; 27(9): 1563-1572. https://doi.org/10.1038/sj.jcbfm.9600462</mixed-citation><mixed-citation xml:lang="en">Stoquart-ElSankari S, Balédent O, Gondry-Jouet C, Makki M, Godefroy O, Meyer ME. Aging eff ects on cerebral blood and cerebrospinal fl uid fl ows. J Cereb Blood Flow Metab. 2007; 27(9): 1563-1572. https://doi.org/10.1038/sj.jcbfm.9600462</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Maeda S, Otani T, Yamada S, Watanabe Y, Ilik SY, Wada S. Biomechanical eff ects of hyper-dynamic cerebrospinal fl uid fl ow through the cerebral aqueduct in idiopathic normal pressure hydrocephalus patients. J Biomech. 2023; 156: 111671. https://doi.org/10.1016/j.jbiomech.2023.111671</mixed-citation><mixed-citation xml:lang="en">Maeda S, Otani T, Yamada S, Watanabe Y, Ilik SY, Wada S. Biomechanical eff ects of hyper-dynamic cerebrospinal fl uid fl ow through the cerebral aqueduct in idiopathic normal pressure hydrocephalus patients. J Biomech. 2023; 156: 111671. https://doi.org/10.1016/j.jbiomech.2023.111671</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Giorgio C, Marcello L, Enricomaria M, Concetta A, Antonello C, Antonino G, et al. Magnetic resonance imaging diagnosis in normal pressure hydrocephalus. World Neurosurg. 2024; 181: 171-177. https://doi.org/10.1016/j.wneu.2023.10.110</mixed-citation><mixed-citation xml:lang="en">Giorgio C, Marcello L, Enricomaria M, Concetta A, Antonello C, Antonino G, et al. Magnetic resonance imaging diagnosis in normal pressure hydrocephalus. World Neurosurg. 2024; 181: 171-177. https://doi.org/10.1016/j.wneu.2023.10.110</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Br G, Sharma PK, Polaka Y, S P, Natarajan P. The role of phase-contrast MRI in diagnosing cerebrospinal fl uid fl ow abnormalities. Cureus. 2024; 16(3): e57114. https://doi.org/10.7759/cureus.57114</mixed-citation><mixed-citation xml:lang="en">Br G, Sharma PK, Polaka Y, S P, Natarajan P. The role of phase-contrast MRI in diagnosing cerebrospinal fl uid fl ow abnormalities. Cureus. 2024; 16(3): e57114. https://doi.org/10.7759/cureus.57114</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Brutigam K, Vakis A, Tsitsipanis C. Pathogenesis of idiopathic normal pressure hydrocephalus: A review of knowledge. J Clin Neurosci. 2019; 61: 10-13. https://doi.org/10.1016/j.jocn.2018.10.147</mixed-citation><mixed-citation xml:lang="en">Brutigam K, Vakis A, Tsitsipanis C. Pathogenesis of idiopathic normal pressure hydrocephalus: A review of knowledge. J Clin Neurosci. 2019; 61: 10-13. https://doi.org/10.1016/j.jocn.2018.10.147</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Aunan-Diop JS, Pedersen CB, Halle B, Jensen U, Munthe S, Harbo F, et al. Magnetic resonance elastography in normal pressure hydrocephalus – A scoping review. Neurosurg Rev. 2022; 45(2): 1157-1169. https://doi.org/10.1007/s10143-021-01669-0</mixed-citation><mixed-citation xml:lang="en">Aunan-Diop JS, Pedersen CB, Halle B, Jensen U, Munthe S, Harbo F, et al. Magnetic resonance elastography in normal pressure hydrocephalus – A scoping review. Neurosurg Rev. 2022; 45(2): 1157-1169. https://doi.org/10.1007/s10143-021-01669-0</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Kim DJ, Czosnyka Z, Kasprowicz M, Smieleweski P, Baledent O, Guerguerian AM, et al. Continuous monitoring of the Monro-Kellie doctrine: Is it possible? J Neurotrauma. 2012; 29(7): 1354-1363. https://doi.org/10.1089/neu.2011.2018</mixed-citation><mixed-citation xml:lang="en">Kim DJ, Czosnyka Z, Kasprowicz M, Smieleweski P, Baledent O, Guerguerian AM, et al. Continuous monitoring of the Monro-Kellie doctrine: Is it possible? J Neurotrauma. 2012; 29(7): 1354-1363. https://doi.org/10.1089/neu.2011.2018</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Qvarlander S, Ambarki K, Wåhlin A, Jacobsson J. Cerebrospinal fl uid and blood fl ow patterns in idiopathic normal pressure hydrocephalus. Acta Neurol Scand. 2017; 135(5): 576-584. https://doi.org/10.1111/ane.12636</mixed-citation><mixed-citation xml:lang="en">Qvarlander S, Ambarki K, Wåhlin A, Jacobsson J. Cerebrospinal fl uid and blood fl ow patterns in idiopathic normal pressure hydrocephalus. Acta Neurol Scand. 2017; 135(5): 576-584. https://doi.org/10.1111/ane.12636</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Czosnyka M, Czosnyka ZH, Whitfi eld PC, Donovan T, Pickard JD. Age dependence of cerebrospinal pressure-volume compensation in patients with hydrocephalus. J Neurosurg. 2001; 94(3): 482-486. https://doi.org/10.3171/jns.2001.94.3.0482</mixed-citation><mixed-citation xml:lang="en">Czosnyka M, Czosnyka ZH, Whitfi eld PC, Donovan T, Pickard JD. Age dependence of cerebrospinal pressure-volume compensation in patients with hydrocephalus. J Neurosurg. 2001; 94(3): 482-486. https://doi.org/10.3171/jns.2001.94.3.0482</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Bradley WG Jr. CSF fl ow in the brain in the context of normal pressure hydrocephalus. AJNR Am J Neuroradiol. 2015; 36(5): 831-838. https://doi.org/10.3174/ajnr.A4124</mixed-citation><mixed-citation xml:lang="en">Bradley WG Jr. CSF fl ow in the brain in the context of normal pressure hydrocephalus. AJNR Am J Neuroradiol. 2015; 36(5): 831-838. https://doi.org/10.3174/ajnr.A4124</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">ВолодинНН, МедведевМИ, ГорбуновАВ. Компьютерная томография головного мозга уноворожденных идетей раннего возраста: иллюстрированное руководство дляврачей. М.: ГЭОТАР-Мед; 2002.</mixed-citation><mixed-citation xml:lang="en">Volodin NN, Medvedev MI, Gorbunov AV. Computed tomography of the brain in newborns and young children: Illustrated guide for doctors. Moscow: GEOTAR-Med; 2002. (In Russ.)].</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">КорниенкоВН, ПронинИН. Диагностическая нейрорадиология. М.: ИП АндрееваТ.М.; 2006. [Kornienko VN, Pronin IN. Diagnostic neuroradiology. Moscow: IP Andreeva T.M.; 2006. (In Russ.)].</mixed-citation><mixed-citation xml:lang="en">Kornienko VN, Pronin IN. Diagnostic neuroradiology. Moscow: IP Andreeva T.M.; 2006. (In Russ.)].</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">ТуркинАМ, АфандиевРМ, Мельникова-ПицхелауриТВ., ФадееваЛМ, СоложенцеваКД, ПогосбекянЭЛ, идр. Перивентрикулярные изменения пригидроцефалии: количественная оценка тканевых характеристик методом магнитно-резонансной томографии. Журнал Вопросы нейрохирургии имени Н.Н.Бурденко. 2022; 86(4): 41-49. https://doi.org/10.17116/neiro20228604141</mixed-citation><mixed-citation xml:lang="en">Turkin AM, Afandiev RM, Melnikova-Pitskhelauri TV, Fadeeva LM, Solozhentseva KD, Pogosbekyan EL, et al. Periventricular changes following hydrocephalus: quantitative MR-based assessment of tissue characteristics. Burdenko’s Journal of Neurosurgery. 2022; 86(4): 41-49. (In Russ.)]. https://doi.org/10.17116/neiro20228604141</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Carswell C. Idiopathic normal pressure hydrocephalus: Historical context and a contemporary guide. Pract Neurol. 2023; 23(1): 15-22. https://doi.org/10.1136/pn-2021-003291</mixed-citation><mixed-citation xml:lang="en">Carswell C. Idiopathic normal pressure hydrocephalus: Historical context and a contemporary guide. Pract Neurol. 2023; 23(1): 15-22. https://doi.org/10.1136/pn-2021-003291</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Marmarou A, Bergsneider M, Klinge P, Relkin N, Black P. The value of supplemental prognostic tests for the preoperative assessment of idiopathic normal-pressure hydrocephalus: INPH Guidelines, part III. Neurosurgery. 2005; 57(3 Suppl): S17-S28; discussion II-V. https://doi.org/10.1227/01.neu.0000168184.01002.60</mixed-citation><mixed-citation xml:lang="en">Marmarou A, Bergsneider M, Klinge P, Relkin N, Black P. The value of supplemental prognostic tests for the preoperative assessment of idiopathic normal-pressure hydrocephalus: INPH Guidelines, part III. Neurosurgery. 2005; 57(3 Suppl): S17-S28; discussion II-V. https://doi.org/10.1227/01.neu.0000168184.01002.60</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">АфандиевРМ, ФадееваЛМ, СоложенцеваКД, ПронинИН. Возможности магнитно-резонансной томографии воценке гидроцефалии. Вестник рентгенологии ирадиологии. 2021; 102(2): 124-133. https://doi.org/10.20862/0042-4676-2021-102-2-124-133</mixed-citation><mixed-citation xml:lang="en">Afandiev RM, Fadeeva LM, Solozhentseva KD, Pronin IN Magnetic resonance imaging in the evaluation of hydrocephalus. Journal of Radiology and Nuclear Medicine. 2021; 102(2): 124-133. (In Russ.)]. https://doi.org/10.20862/0042-4676-2021-102-2-124-133</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">ЛобзинВЮ, АлизадеМРО, ЛобзинСВ, ЛапинаАВ, КолмаковаКА, ГавриловГВ. идр. Идиопатическая нормотензивная гидроцефалия: современные подходы кдиагностике ивозможности медикаментозного лечения. Эффективная фармакотерапия. 2021; 17(10): 6-12. https://doi.org/10.33978/2307-35862021-17-10-6-12</mixed-citation><mixed-citation xml:lang="en">Lobzin VYu, Alizade MRO, Lobzin SV, Lapina AV, Kolmakova KA, Gavrilov GV, et al. Idiopathic normal pressure hydrocephalus: Modern approaches to diagnostic and possibilities of medicine treatment. Eff ective Pharmacotherapy. 2021; 17(10): 6-12. (In Russ.)]. https://doi.org/10.33978/2307-35862021-17-10-6-12</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Brix MK, Westman E, Simmons A, Ringstad GA, Eide PK, Wagner-Larsen K, et al. The Evans’ index revisited: New cut-off levels for use in radiological assessment of ventricular enlargement in the elderly. Eur J Radiol. 2017; 95: 28-32. https://doi.org/10.1016/j.ejrad.2017.07.013</mixed-citation><mixed-citation xml:lang="en">Brix MK, Westman E, Simmons A, Ringstad GA, Eide PK, Wagner-Larsen K, et al. The Evans’ index revisited: New cut-off  levels for use in radiological assessment of ventricular enlargement in the elderly. Eur J Radiol. 2017; 95: 28-32. https://doi.org/10.1016/j.ejrad.2017.07.013</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Jaraj D, Rabiei K, Marlow T, Jensen C, Skoog I, Wikkelsø C. Estimated ventricle size using Evans index: Reference values from a population-based sample. Eur J Neurol. 2017; 24(3): 468-474. https://doi.org/10.1111/ene.13226</mixed-citation><mixed-citation xml:lang="en">Jaraj D, Rabiei K, Marlow T, Jensen C, Skoog I, Wikkelsø C. Estimated ventricle size using Evans index: Reference values from a population-based sample. Eur J Neurol. 2017; 24(3): 468-474. https://doi.org/10.1111/ene.13226</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Kockum K, Lilja-Lund O, Larsson EM, Rosell M, Söderström L, Virhammar J, et al. The idiopathic normal-pressure hydrocephalus Radscale: A radiological scale for structured evaluation. Eur J Neurol. 2018; 25(3): 569-576. https://doi.org/10.1111/ene.13555</mixed-citation><mixed-citation xml:lang="en">Kockum K, Lilja-Lund O, Larsson EM, Rosell M, Söderström L, Virhammar J, et al. The idiopathic normal-pressure hydrocephalus Radscale: A radiological scale for structured evaluation. Eur J Neurol. 2018; 25(3): 569-576. https://doi.org/10.1111/ene.13555</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Fällmar D, Andersson O, Kilander L, Löwenmark M, Nyholm D, Virhammar J. Imaging features associated with idiopathic normal pressure hydrocephalus have high specifi city even when comparing with vascular dementia and atypical parkinsonism. Fluids Barriers CNS. 2021; 18(1): 35-42. https://doi.org/10.1186/s12987-021-00270-3</mixed-citation><mixed-citation xml:lang="en">Fällmar D, Andersson O, Kilander L, Löwenmark M, Nyholm D, Virhammar J. Imaging features associated with idiopathic normal pressure hydrocephalus have high specifi city even when comparing with vascular dementia and atypical parkinsonism. Fluids Barriers CNS. 2021; 18(1): 35-42. https://doi.org/10.1186/s12987-021-00270-3</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Hattori T, Ohara M, Yuasa T, Azuma R, Chen Q, Hanazawa R, et al. Correlation of callosal angle at the splenium with gait and cognition in normal pressure hydrocephalus. J Neurosurg. 2023; 139(2): 481-491. https://doi.org/10.3171/2022.12.JNS221825</mixed-citation><mixed-citation xml:lang="en">Hattori T, Ohara M, Yuasa T, Azuma R, Chen Q, Hanazawa R, et al. Correlation of callosal angle at the splenium with gait and cognition in normal pressure hydrocephalus. J Neurosurg. 2023; 139(2): 481-491. https://doi.org/10.3171/2022.12.JNS221825</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Yamada S. Neuroimaging of adult hydrocephalus. Neurosurg Clin N Am. 2025; 36(2): 183-197. https://doi.org/10.1016/j.nec.2024.11.007</mixed-citation><mixed-citation xml:lang="en">Yamada S. Neuroimaging of adult hydrocephalus. Neurosurg Clin N Am. 2025; 36(2): 183-197. https://doi.org/10.1016/j.nec.2024.11.007</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Sasaki M, Honda S, Yuasa T, Iwamura A, Shibata E, Ohba H. Narrow CSF space at high convexity and high midline areas in idiopathic normal pressure hydrocephalus detected by axial and coronal MRI. Neuroradiology. 2008; 50(2): 117-122. https://doi.org/10.1007/s00234-007-0318-x</mixed-citation><mixed-citation xml:lang="en">Sasaki M, Honda S, Yuasa T, Iwamura A, Shibata E, Ohba H. Narrow CSF space at high convexity and high midline areas in idiopathic normal pressure hydrocephalus detected by axial and coronal MRI. Neuroradiology. 2008; 50(2): 117-122. https://doi.org/10.1007/s00234-007-0318-x</mixed-citation></citation-alternatives></ref><ref id="cit53"><label>53</label><citation-alternatives><mixed-citation xml:lang="ru">Benedetto N, Gambacciani C, Aquila F, Di Carlo DT, Morganti R, Perrini P. A new quantitative method to assess disproportionately enlarged subarachnoid space (DESH) in patients with possible idiopathic normal pressure hydrocephalus: The SILVER index. Clin Neurol Neurosurg. 2017; 158: 27-32. https://doi.org/10.1016/j.clineuro.2017.04.015</mixed-citation><mixed-citation xml:lang="en">Benedetto N, Gambacciani C, Aquila F, Di Carlo DT, Morganti R, Perrini P. A new quantitative method to assess disproportionately enlarged subarachnoid space (DESH) in patients with possible idiopathic normal pressure hydrocephalus: The SILVER index. Clin Neurol Neurosurg. 2017; 158: 27-32. https://doi.org/10.1016/j.clineuro.2017.04.015</mixed-citation></citation-alternatives></ref><ref id="cit54"><label>54</label><citation-alternatives><mixed-citation xml:lang="ru">Kitagaki H, Mori E, Ishii K, Yamaji S, Hirono N, Imamura T. CSF spaces in idiopathic normal pressure hydrocephalus: Morphology and volumetry. AJNR Am J Neuroradiol. 1998; 19(7): 1277-1284.</mixed-citation><mixed-citation xml:lang="en">Kitagaki H, Mori E, Ishii K, Yamaji S, Hirono N, Imamura T. CSF spaces in idiopathic normal pressure hydrocephalus: Morphology and volumetry. AJNR Am J Neuroradiol. 1998; 19(7): 1277-1284.</mixed-citation></citation-alternatives></ref><ref id="cit55"><label>55</label><citation-alternatives><mixed-citation xml:lang="ru">Agerskov S, Wallin M, Hellström P, Ziegelitz D, Wikkelsö C, Tullberg M. Absence of disproportionately enlarged subarachnoid space hydrocephalus, a sharp callosal angle, or other morphologic MRI markers should not be used to exclude patients with idiopathic normal pressure hydrocephalus from shunt surgery. AJNR Am J Neuroradiol. 2019; 40(1): 74-79. https://doi.org/10.3174/ajnr.A5910</mixed-citation><mixed-citation xml:lang="en">Agerskov S, Wallin M, Hellström P, Ziegelitz D, Wikkelsö C, Tullberg M. Absence of disproportionately enlarged subarachnoid space hydrocephalus, a sharp callosal angle, or other morphologic MRI markers should not be used to exclude patients with idiopathic normal pressure hydrocephalus from shunt surgery. AJNR Am J Neuroradiol. 2019; 40(1): 74-79. https://doi.org/10.3174/ajnr.A5910</mixed-citation></citation-alternatives></ref><ref id="cit56"><label>56</label><citation-alternatives><mixed-citation xml:lang="ru">Milhorat TH, Clark RG, Hammock MK, McGrath PP. Structural, ultrastructural, and permeability changes in the ependyma and surrounding brain favoring equilibration in progressive hydrocephalus. Arch Neurol. 1970; 22(5): 397-407. https://doi.org/10.1001/archneur.1970.00480230015002</mixed-citation><mixed-citation xml:lang="en">Milhorat TH, Clark RG, Hammock MK, McGrath PP. Structural, ultrastructural, and permeability changes in the ependyma and surrounding brain favoring equilibration in progressive hydrocephalus. Arch Neurol. 1970; 22(5): 397-407. https://doi.org/10.1001/archneur.1970.00480230015002</mixed-citation></citation-alternatives></ref><ref id="cit57"><label>57</label><citation-alternatives><mixed-citation xml:lang="ru">Virhammar J, Laurell K, Cesarini KG, Larsson EM. The callosal angle measured on MRI as a predictor of outcome in idiopathic normal-pressure hydrocephalus. J Neurosurg. 2014; 120(1): 178-184. https://doi.org/10.3171/2013.8.JNS13575</mixed-citation><mixed-citation xml:lang="en">Virhammar J, Laurell K, Cesarini KG, Larsson EM. The callosal angle measured on MRI as a predictor of outcome in idiopathic normal-pressure hydrocephalus. J Neurosurg. 2014; 120(1): 178-184. https://doi.org/10.3171/2013.8.JNS13575</mixed-citation></citation-alternatives></ref><ref id="cit58"><label>58</label><citation-alternatives><mixed-citation xml:lang="ru">Ishii K, Kanda T, Harada A, Miyamoto N, Kawaguchi T, Shimada K, et al. Clinical impact of the callosal angle in the diagnosis of idiopathic normal pressure hydrocephalus. Eur Radiol. 2008; 18(11): 2678-2683. https://doi.org/10.1007/s00330-008-1044-4</mixed-citation><mixed-citation xml:lang="en">Ishii K, Kanda T, Harada A, Miyamoto N, Kawaguchi T, Shimada K, et al. Clinical impact of the callosal angle in the diagnosis of idiopathic normal pressure hydrocephalus. Eur Radiol. 2008; 18(11): 2678-2683. https://doi.org/10.1007/s00330-008-1044-4</mixed-citation></citation-alternatives></ref><ref id="cit59"><label>59</label><citation-alternatives><mixed-citation xml:lang="ru">Mori E, Ishikawa M, Kato T, Kazui H, Miyake H, Miyajima M, et al; Japanese Society of Normal Pressure Hydrocephalus. Guidelines for management of idiopathic normal pressure hydrocephalus: Second edition. Neurol Med Chir (Tokyo). 2012; 52(11): 775-809. https://doi.org/10.2176/nmc.52.775</mixed-citation><mixed-citation xml:lang="en">Mori E, Ishikawa M, Kato T, Kazui H, Miyake H, Miyajima M, et al; Japanese Society of Normal Pressure Hydrocephalus. Guidelines for management of idiopathic normal pressure hydrocephalus: Second edition. Neurol Med Chir (Tokyo). 2012; 52(11): 775-809. https://doi.org/10.2176/nmc.52.775</mixed-citation></citation-alternatives></ref><ref id="cit60"><label>60</label><citation-alternatives><mixed-citation xml:lang="ru">Hamilton MG, Williams MA, Edwards S, Tullberg M. Guidelines for diagnosis and management of idiopathic normal pressure hydrocephalus. Neurosurg Clin N Am. 2025; 36(2): 199-205. https://doi.org/10.1016/j.nec.2024.12.006</mixed-citation><mixed-citation xml:lang="en">Hamilton MG, Williams MA, Edwards S, Tullberg M. Guidelines for diagnosis and management of idiopathic normal pressure hydrocephalus. Neurosurg Clin N Am. 2025; 36(2): 199-205. https://doi.org/10.1016/j.nec.2024.12.006</mixed-citation></citation-alternatives></ref><ref id="cit61"><label>61</label><citation-alternatives><mixed-citation xml:lang="ru">Evans WA. An encephalographic ratio for estimating ventricular enlargement and cerebral atrophy. Arch Neurol Psychiatry. 1942; (47): 931-937.</mixed-citation><mixed-citation xml:lang="en">Evans WA. An encephalographic ratio for estimating ventricular enlargement and cerebral atrophy. Arch Neurol Psychiatry. 1942; (47): 931-937.</mixed-citation></citation-alternatives></ref><ref id="cit62"><label>62</label><citation-alternatives><mixed-citation xml:lang="ru">Fazekas F, Barkhof F, Wahlund LO, Pantoni L, Erkinjuntti T, Scheltens P, et al. CT and MRI rating of white matter lesions. Cerebrovasc Dis. 2002; 13(Suppl 2): 31-36.</mixed-citation><mixed-citation xml:lang="en">Fazekas F, Barkhof F, Wahlund LO, Pantoni L, Erkinjuntti T, Scheltens P, et al. CT and MRI rating of white matter lesions. Cerebrovasc Dis. 2002; 13(Suppl 2): 31-36.</mixed-citation></citation-alternatives></ref><ref id="cit63"><label>63</label><citation-alternatives><mixed-citation xml:lang="ru">Holodny AI, George AE, de Leon MJ, Golomb J, Kalnin AJ, Cooper PR. Focal dilation and paradoxical collapse of cortical fi ssures and sulci in patients with normal-pressure hydrocephalus. J Neurosurg. 1998; 89(5): 742-747.</mixed-citation><mixed-citation xml:lang="en">Holodny AI, George AE, de Leon MJ, Golomb J, Kalnin AJ, Cooper PR. Focal dilation and paradoxical collapse of cortical fi ssures and sulci in patients with normal-pressure hydrocephalus. J Neurosurg. 1998; 89(5): 742-747.</mixed-citation></citation-alternatives></ref><ref id="cit64"><label>64</label><citation-alternatives><mixed-citation xml:lang="ru">Virhammar J, Laurell K, Cesarini KG, Larsson EM. Increase in callosal angle and decrease in ventricular volume after shunt surgery in patients with idiopathic normal pressure hydrocephalus. J Neurosurg. 2019; 130(1): 130-135. https://doi.org/10.3171/2017.8.JNS17547</mixed-citation><mixed-citation xml:lang="en">Virhammar J, Laurell K, Cesarini KG, Larsson EM. Increase in callosal angle and decrease in ventricular volume after shunt surgery in patients with idiopathic normal pressure hydrocephalus. J Neurosurg. 2019; 130(1): 130-135. https://doi.org/10.3171/2017.8.JNS17547</mixed-citation></citation-alternatives></ref><ref id="cit65"><label>65</label><citation-alternatives><mixed-citation xml:lang="ru">Kockum K, Virhammar J, Riklund K, Söderström L, Larsson EM, Laurell K. Diagnostic accuracy of the iNPH Radscale in idiopathic normal pressure hydrocephalus. PLoS One. 2020; 15(4): e0232275. https://doi.org/10.1371/journal.pone.0232275</mixed-citation><mixed-citation xml:lang="en">Kockum K, Virhammar J, Riklund K, Söderström L, Larsson EM, Laurell K. Diagnostic accuracy of the iNPH Radscale in idiopathic normal pressure hydrocephalus. PLoS One. 2020; 15(4): e0232275. https://doi.org/10.1371/journal.pone.0232275</mixed-citation></citation-alternatives></ref><ref id="cit66"><label>66</label><citation-alternatives><mixed-citation xml:lang="ru">Miskin N, Patel H, Franceschi AM, Ades-Aron B, Le A, Damadian BE, et al. Diagnosis of normal-pressure hydrocephalus: Use of traditional measures in the era of volumetric MR imaging. Radiology. 2017; 285(1): 197-205.</mixed-citation><mixed-citation xml:lang="en">Miskin N, Patel H, Franceschi AM, Ades-Aron B, Le A, Damadian BE, et al. Diagnosis of normal-pressure hydrocephalus: Use of traditional measures in the era of volumetric MR imaging. Radiology. 2017; 285(1): 197-205.</mixed-citation></citation-alternatives></ref><ref id="cit67"><label>67</label><citation-alternatives><mixed-citation xml:lang="ru">Chen J, He W, Zhang X, Lv M, Zhou X, Yang X, et al. Value of MRI-based semi-quantitative structural neuroimaging in predicting the prognosis of patients with idiopathic normal pressure hydrocephalus after shunt surgery. Eur Radiol. 2022; 32(11): 7800-7810. https://doi.org/10.1007/s00330-02208733-3</mixed-citation><mixed-citation xml:lang="en">Chen J, He W, Zhang X, Lv M, Zhou X, Yang X, et al. Value of MRI-based semi-quantitative structural neuroimaging in predicting the prognosis of patients with idiopathic normal pressure hydrocephalus after shunt surgery. Eur Radiol. 2022; 32(11): 7800-7810. https://doi.org/10.1007/s00330-02208733-3</mixed-citation></citation-alternatives></ref><ref id="cit68"><label>68</label><citation-alternatives><mixed-citation xml:lang="ru">Kumari S, Ranjan R. CSF fl owmetry: An innovative technique in diagnosing normal pressure hydrocephalus. Int J Curr Pharmaceut Rev Res. 2024; 16(2): 564-568. https://doi.org/10.5281/zenodo.12799108</mixed-citation><mixed-citation xml:lang="en">Kumari S, Ranjan R. CSF fl owmetry: An innovative technique in diagnosing normal pressure hydrocephalus. Int J Curr Pharmaceut Rev Res. 2024; 16(2): 564-568. https://doi.org/10.5281/zenodo.12799108</mixed-citation></citation-alternatives></ref><ref id="cit69"><label>69</label><citation-alternatives><mixed-citation xml:lang="ru">Algin O, Hakyemez B, Taskapilioglu O, Ocakoglu G, Bekar A, Parlak M. Morphologic features and fl ow void phenomenon in normal pressure hydrocephalus and other dementias: Are they really signifi cant? Acad Radiol. 2009; 16(11): 1373-1380. https://doi.org/10.1016/j.acra.2009.06.010</mixed-citation><mixed-citation xml:lang="en">Algin O, Hakyemez B, Taskapilioglu O, Ocakoglu G, Bekar A, Parlak M. Morphologic features and fl ow void phenomenon in normal pressure hydrocephalus and other dementias: Are they really signifi cant? Acad Radiol. 2009; 16(11): 1373-1380. https://doi.org/10.1016/j.acra.2009.06.010</mixed-citation></citation-alternatives></ref><ref id="cit70"><label>70</label><citation-alternatives><mixed-citation xml:lang="ru">Shanks J, Markenroth Bloch K, Laurell K, Cesarini KG, Fahlström M, Larsson EM, et al. Aqueductal CSF stroke volume is increased in patients with idiopathic normal pressure hydrocephalus and decreases after shunt surgery. AJNR Am J Neuroradiol. 2019; 40(3): 453-459. https://doi.org/10.3174/ajnr.A5972</mixed-citation><mixed-citation xml:lang="en">Shanks J, Markenroth Bloch K, Laurell K, Cesarini KG, Fahlström M, Larsson EM, et al. Aqueductal CSF stroke volume is increased in patients with idiopathic normal pressure hydrocephalus and decreases after shunt surgery. AJNR Am J Neuroradiol. 2019; 40(3): 453-459. https://doi.org/10.3174/ajnr.A5972</mixed-citation></citation-alternatives></ref><ref id="cit71"><label>71</label><citation-alternatives><mixed-citation xml:lang="ru">Ringstad G, Vatnehol SAS, Eide PK. Glymphatic MRI in idiopathic normal pressure hydrocephalus. Brain. 2017; 140(10): 2691-2705. https://doi.org/10.1093/brain/awx191</mixed-citation><mixed-citation xml:lang="en">Ringstad G, Vatnehol SAS, Eide PK. Glymphatic MRI in idiopathic normal pressure hydrocephalus. Brain. 2017; 140(10): 2691-2705. https://doi.org/10.1093/brain/awx191</mixed-citation></citation-alternatives></ref><ref id="cit72"><label>72</label><citation-alternatives><mixed-citation xml:lang="ru">Hashimoto M, Ishikawa M, Mori E, Kuwana N; Study of INPH on neurological improvement (SINPHONI). Diagnosis of idiopathic normal pressure hydrocephalus is supported by MRI-based scheme: A prospective cohort study. Cerebrospinal Fluid Res. 2010; 7: 18-27. https://doi.org/10.1186/1743-8454-7-18</mixed-citation><mixed-citation xml:lang="en">Hashimoto M, Ishikawa M, Mori E, Kuwana N; Study of INPH on neurological improvement (SINPHONI). Diagnosis of idiopathic normal pressure hydrocephalus is supported by MRI-based scheme: A prospective cohort study. Cerebrospinal Fluid Res. 2010; 7: 18-27. https://doi.org/10.1186/1743-8454-7-18</mixed-citation></citation-alternatives></ref><ref id="cit73"><label>73</label><citation-alternatives><mixed-citation xml:lang="ru">Narita W, Nishio Y, Baba T, Iizuka O, Ishihara T, Matsuda M, et al. High-convexity tightness predicts the shunt response in idiopathic normal pressure hydrocephalus. AJNR Am J Neuroradiol. 2016; 37(10): 1831-1837. https://doi.org/10.3174/ajnr.A4838</mixed-citation><mixed-citation xml:lang="en">Narita W, Nishio Y, Baba T, Iizuka O, Ishihara T, Matsuda M, et al. High-convexity tightness predicts the shunt response in idiopathic normal pressure hydrocephalus. AJNR Am J Neuroradiol. 2016; 37(10): 1831-1837. https://doi.org/10.3174/ajnr.A4838</mixed-citation></citation-alternatives></ref><ref id="cit74"><label>74</label><citation-alternatives><mixed-citation xml:lang="ru">Bateman GA, Bateman AR. Diff erences in the calculated transvenous pressure drop between chronic hydrocephalus and idiopathic intracranial hypertension. AJNR Am J Neuroradiol. 2019; 40(1): 68-73. https://doi.org/10.3174/ajnr.A5883</mixed-citation><mixed-citation xml:lang="en">Bateman GA, Bateman AR. Diff erences in the calculated transvenous pressure drop between chronic hydrocephalus and idiopathic intracranial hypertension. AJNR Am J Neuroradiol. 2019; 40(1): 68-73. https://doi.org/10.3174/ajnr.A5883</mixed-citation></citation-alternatives></ref><ref id="cit75"><label>75</label><citation-alternatives><mixed-citation xml:lang="ru">Relkin N, Marmarou A, Klinge P, Bergsneider M, Black P. Diagnosing idiopathic normal-pressure hydrocephalus. Neurosurgery. 2005; 57(3 Suppl): S4-S16; discussion II-V. https://doi.org/10.1227/01.NEU.0000168185.29659.C5</mixed-citation><mixed-citation xml:lang="en">Relkin N, Marmarou A, Klinge P, Bergsneider M, Black P. Diagnosing idiopathic normal-pressure hydrocephalus. Neurosurgery. 2005; 57(3 Suppl): S4-S16; discussion II-V. https://doi.org/10.1227/01.NEU.0000168185.29659.C5</mixed-citation></citation-alternatives></ref><ref id="cit76"><label>76</label><citation-alternatives><mixed-citation xml:lang="ru">Craven CL, Toma AK, Mostafa T, Patel N, Watkins LD. The predictive value of DESH for shunt responsiveness in idiopathic normal pressure hydrocephalus. J Clin Neurosci. 2016; 34: 294-298. https://doi.org/10.1016/j.jocn.2016.09.004</mixed-citation><mixed-citation xml:lang="en">Craven CL, Toma AK, Mostafa T, Patel N, Watkins LD. The predictive value of DESH for shunt responsiveness in idiopathic normal pressure hydrocephalus. J Clin Neurosci. 2016; 34: 294-298. https://doi.org/10.1016/j.jocn.2016.09.004</mixed-citation></citation-alternatives></ref><ref id="cit77"><label>77</label><citation-alternatives><mixed-citation xml:lang="ru">Shinoda N, Hirai O, Hori S, Mikami K, Bando T, Shimo D, et al. Utility of MRI-based disproportionately enlarged subarachnoid space hydrocephalus scoring for predicting prognosis after surgery for idiopathic normal pressure hydrocephalus: Clinical research. J Neurosurg. 2017; 127: 14361442. https://doi.org/10.3171/2016.9.JNS161080</mixed-citation><mixed-citation xml:lang="en">Shinoda N, Hirai O, Hori S, Mikami K, Bando T, Shimo D, et al. Utility of MRI-based disproportionately enlarged subarachnoid space hydrocephalus scoring for predicting prognosis after surgery for idiopathic normal pressure hydrocephalus: Clinical research. J Neurosurg. 2017; 127: 14361442. https://doi.org/10.3171/2016.9.JNS161080</mixed-citation></citation-alternatives></ref><ref id="cit78"><label>78</label><citation-alternatives><mixed-citation xml:lang="ru">Badagard H, Braun M, Nilsson D, Stridh L, Virhammar J. Negative predictors of shunt surgery outcome in normal pressure hydrocephalus. Acta Neurol Scand. 2020; 141(3): 219-225.</mixed-citation><mixed-citation xml:lang="en">Badagard H, Braun M, Nilsson D, Stridh L, Virhammar J. Negative predictors of shunt surgery outcome in normal pressure hydrocephalus. Acta Neurol Scand. 2020; 141(3): 219-225.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
