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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">sibneiro</journal-id><journal-title-group><journal-title xml:lang="ru">Сибнейро</journal-title><trans-title-group xml:lang="en"><trans-title>Sibneuro</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">3033-649X</issn><issn pub-type="epub">3033-6805</issn><publisher><publisher-name>Bervitskiy Anatoliy Vladimirovich</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.64265/sibneuro-2025-1-1-68-77</article-id><article-id custom-type="elpub" pub-id-type="custom">sibneiro-22</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group></article-categories><title-group><article-title>Псевдотуморозная реакция на гемостатический материал. Новый подход к лечению на примере клинических случаев</article-title><trans-title-group xml:lang="en"><trans-title>Pseudotumorous reaction to hemostatic material. A new treatment approach illustrated by clinical cases</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7136-0693</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кушель</surname><given-names>Ю. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kushel</surname><given-names>Yu. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кушель Юрий Вадимович – доктор медицинских наук, врач-нейрохирург, ведущий научный сотрудник 2-го нейрохирургического отделения (нейрохирургия детского возраста) </p><p>ул. 4-я Тверская-Ямская, д. 16, г. Москва, 125047 </p></bio><bio xml:lang="en"><p>Yuri V. Kushel – Dr. Sci. (Med.), Neurosurgeon, Leading Researcher of the 2nd Neurosurgical Department (Pediatric Neurosurgery) </p><p>4ya Tverskaya-Yamskaya str., 16, Moscow, 125047 </p></bio><email xlink:type="simple">kuszel@nsi.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3523-9885</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Коновалова</surname><given-names>Е. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Konovalova</surname><given-names>E. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Коновалова Елизавета Игоревна – кандидат медицинских наук, врач-нейрохирург 2-го нейрохирургического отделения (нейрохирургия детского возраста) </p><p>ул. 4-я Тверская-Ямская, д. 16, г. Москва, 125047 </p></bio><bio xml:lang="en"><p>Elizaveta I. Konovalova – Cand. Sci. (Med.), Neurosurgeon of the 2nd Neurosurgical Department (Pediatric Neurosurgery) </p><p>4ya Tverskaya-Yamskaya str., 16, Moscow, 125047 </p></bio><email xlink:type="simple">elisabeth-snu@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8534-5213</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Демин</surname><given-names>М. О.</given-names></name><name name-style="western" xml:lang="en"><surname>Demin</surname><given-names>M. O.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Демин Максим Олегович – кандидат медицинских наук, врач-нейрохирург 2-го нейрохирургического отделения (нейрохирургия детского возраста) </p><p>ул. 4-я Тверская-Ямская, д. 16, г. Москва, 125047 </p></bio><bio xml:lang="en"><p>Maxim O. Demin – Cand. Sci. (Med.), Neurosurgeon of the 2nd Neurosurgical Department (Pediatric Neurosurgery) </p><p>4ya Tverskaya-Yamskaya str., 16, Moscow, 125047 </p></bio><email xlink:type="simple">mdemin@nsi.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУ «Национальный медицинский исследовательский центр нейрохирургии имени академика Н.Н. Бурденко» Минздрава России</institution></aff><aff xml:lang="en"><institution>N.N. Burdenko National Medical Research Center for Neurosurgery</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>14</day><month>10</month><year>2025</year></pub-date><volume>1</volume><issue>1</issue><fpage>68</fpage><lpage>77</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Кушель Ю.В., Коновалова Е.И., Демин М.О., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Кушель Ю.В., Коновалова Е.И., Демин М.О.</copyright-holder><copyright-holder xml:lang="en">Kushel Y.V., Konovalova E.I., Demin M.O.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.sibneurojournal.com/jour/article/view/22">https://www.sibneurojournal.com/jour/article/view/22</self-uri><abstract><sec><title>Введение</title><p>Введение. Эффективный гемостаз имеет ключевое значение в нейрохирургии, особенно при операциях на границе опухоль/мозг, где классические методы остановки кровотечения могут быть недостаточно эффективны. Оксицеллюлозный материал, широко применяемый в таких операциях (в наших операционных – Surgicel®, один из самых популярных материалов), в редких случаях вызывает гранулематозные реакции, которые могут имитировать рецидив опухоли или абсцесс.</p></sec><sec><title>Цель исследования</title><p>Цель исследования. Рассмотреть два клинических примера воспалительной реакции на гемостатический материал с успешным консервативным лечением и обсудить существующую литературу по данной проблеме.</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы. Приведены клинические случаи двух пациентов (17 и 10 лет), перенесших нейрохирургические операции с использованием оксицеллюлозных гемостатиков, после которых развилась воспалительная реакция на материал. В обоих случаях проведена противовоспалительная терапия с использованием преднизолона, что привело к полной регрессии симптомов.</p></sec><sec><title>Результаты</title><p>Результаты. У обоих пациентов отмечалась типичная клиническая картина воспалительной реакции на гемостатический материал, что подтверждалось нейровизуализационными (магнитно-резонансная томография) и лабораторными данными. Противовоспалительное лечение преднизолоном дало быстрый терапевтический эффект, позволив избежать повторной операции. Реакция на гемостатический материал, такая как гранулематозное воспаление, требует тщательной дифференциальной диагностики с рецидивом опухоли и абсцессом. В стабильных случаях возможно успешное консервативное лечение, что позволяет избежать ненужных хирургических вмешательств.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Introduction</title><p>Introduction. Effective hemostasis is crucial in neurosurgical operations at the tumor/brain interface, where classical methods of bleeding control may be insufficient. The widely used oxidized cellulose material (Surgicel®, one of the most popular materials used in our operating rooms) rarely causes granulomatous reactions that can mimic tumor recurrence or an abscess. Objective of the study was to review two clinical cases of an inflammatory reaction to a hemostatic agent with successful conservative treatment and to discuss the existing literature on this issue.</p></sec><sec><title>Materials and methods</title><p>Materials and methods. We present the clinical cases of two patients (17 and 10 years old) who underwent neurosurgical operations using oxidized cellulose hemostatic agents, after which an inflammatory reaction to the material developed. In both cases, anti-inflammatory therapy with prednisolone was administered, leading to the complete regression of symptoms, including radiological findings.</p></sec><sec><title>Results</title><p>Results. Both patients exhibited a typical clinical picture of an inflammatory reaction to the hemostatic material, confirmed by neuroimaging (MRI) and laboratory data. Anti-inflammatory treatment with prednisolone provided a rapid therapeutic effect, avoiding the need for reoperation.</p></sec><sec><title>Conclusions</title><p>Conclusions. A reaction to the hemostatic material, such as granulomatous inflammation, requires careful differential diagnosis from tumor recurrence and abscess. In stable cases, successful conservative treatment is possible, avoiding unnecessary surgical interventions.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>глиальные опухоли</kwd><kwd>хирургическое лечение опухолей ЦНС</kwd><kwd>гемостатические средства</kwd><kwd>оксицеллюлоза</kwd><kwd>гранулема</kwd><kwd>абсцесс</kwd><kwd>рецидив глиальной опухоли</kwd></kwd-group><kwd-group xml:lang="en"><kwd>glial tumors</kwd><kwd>surgical treatment of CNS tumors</kwd><kwd>hemostatic agents</kwd><kwd>oxidized cellulose</kwd><kwd>granuloma</kwd><kwd>abscess</kwd><kwd>glial tumor recurrence</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Huang L, Liu GL, Kaye AD, Liu H. Advances in topical hemostatic agent therapies: A comprehensive update. 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