sibneiroСибнейроSibneuro3033-649X3033-6805Bervitskiy Anatoliy Vladimirovich10.64265/3033-649X-2026.2.3.89-95sibneiro-129Research ArticleКЛИНИЧЕСКИЕ СЛУЧАИCLINICAL CASESИдиопатическая внутричерепная гипертензия у детей: литературный обзор, клинический случай из практикиIdiopathic intracranial hypertension in children: A literature review and a clinical case studyhttps://orcid.org/0009-0002-4798-007XБолотниковаИ. В.BolotnikovaI. V.

Болотникова Ирина Викторовна – врач-офтальмолог отделения нейрохирургии для детей № 7.

ул. Аккуратова, 2, Санкт-Петербург, 197341

Irina V. Bolotnikova – Ophthalmologist at the Department of Pediatric Neurosurgery No. 7, Almazov National Medical Research Centre.

Akkuratova str., 2, Saint Petersburg, 197341

rika84@yandex.ruhttps://orcid.org/0000-0003-0758-067XНиколаенкоМ. С.NikolaenkoM. S.

Николаенко Михаил Сергеевич – кандидат медицинских наук, врач-нейрохирург отделения нейрохирургии для детей № 7.

ул. Аккуратова, 2, Санкт-Петербург, 197341

Mikhail S. Nikolaenko – Cand. Sci. (Med.), Neurosurgeon at the Department of Pediatric Neurosurgery No. 7, Almazov National Medical Research Centre.

Akkuratova str., 2, Saint Petersburg, 197341

msnikolaenko@mail.ruhttps://orcid.org/0000-0001-7361-0270БржескийВ. В.BrzheskiyV. V.

Бржеский Владимир Всеволодович – доктор медицинских наук, профессор, заведующий кафедрой офтальмологии.

ул. Литовская, 2, Санкт-Петербург, 194100

Vladimir V. Brzheskiy – Dr. Sci. (Med.), Professor, Head of the Department of Ophthalmology, Saint Petersburg State Pediatric Medical University.

Litovskaya str., 2, Saint Petersburg, 194100

vvbrzh@yandex.ruhttps://orcid.org/0000-0002-6219-7270КимА. В.KimA. V.

Ким Александр Вонгиевич – доктор медицинских наук, доцент кафедры нейрохирургии Института медицинского образования, заведующий отделением нейрохирургии для детей № 7.

ул. Аккуратова, 2, Санкт-Петербург, 197341

Aleksandr V. Kim – Dr. Sci. (Med.), Associate Professor at the Department of Neurosurgery, Institute of Medical Education, Head of the Department of Pediatric Neurosurgery No. 7, Almazov National Medical Research Centre.

Akkuratova str., 2, Saint Petersburg, 197341

kimoza@mail.ruНациональный медицинский исследовательский центр имени В.А. АлмазоваРоссияAlmazov National Medical Research CentreRussian FederationСанкт-Петербургский государственный педиатрический медицинский университетРоссияSaint Petersburg State Pediatric Medical UniversityRussian Federation202617102026238995Copyright © Болотникова И.В., Николаенко М.С., Бржеский В.В., Ким А.В., 20262026Болотникова И.В., Николаенко М.С., Бржеский В.В., Ким А.В.Bolotnikova I.V., Nikolaenko M.S., Brzheskiy V.V., Kim A.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.sibneurojournal.com/jour/article/view/129Введение

Введение. В последнее время появляются новые сведения об этиологии и патофизиологических механизмах развития идиопатической внутричерепной гипертензии у детей.

Описание клинического случая. В предлагаемой работе представлен обзор литературных данных за последние 10 лет, произведен разбор клинического случая возникновения идиопатической внутричерепной гипертензии у двенадцатилетней пациентки с ожирением. Клиническая картина заболевания у детей и данные медицинских обследований имеют некоторые особенности в сравнении с таковыми у взрослых пациентов.

Заключение

Заключение. Таким образом, целесообразно более детальное офтальмологическое и нейрохирургическое обследование данной группы пациентов для раннего выявления заболевания и определение щадящей и эффективной тактики лечения.

Introduction

Introduction. Recently, new data have emerged regarding the etiology and pathophysiological mechanisms of idiopathic intracranial hypertension in children.

Clinical case description. This paper presents a review of the literature over the past 10 years and analyzes a clinical case of idiopathic intracranial hypertension in a twelve-year-old female patient with obesity. The clinical presentation of the disease in children and the findings from medical examinations have certain features that differ from those in adults.

Conclusion

Conclusion. Thus, a more detailed ophthalmological and neurosurgical evaluation of this patient group is advisable for early detection of the disease and for determining a safe and effective treatment strategy.

идиопатическая внутричерепная гипертензиязастойные диски зрительных нервоввнутричерепная венозная гипертензияidiopathic intracranial hypertensionpapilledemaintracranial venous hypertensionReferencesSeay MD, Digre KB. Idiopathic intracranial hypertension from benign to fulminant: Diagnostic and management issues. Ann Indian Acad Neurol. 2022; 25(Suppl 2): 59-S64. https://doi.org/10.4103/aian.aian_203_22Seay MD, Digre KB. Idiopathic intracranial hypertension from benign to fulminant: Diagnostic and management issues. Ann Indian Acad Neurol. 2022; 25(Suppl 2): 59-S64. https://doi.org/10.4103/aian.aian_203_22Burkett JG, Ailani J. An up-to-date review of pseudotumor cerebri syndrome. Curr Neurol Neurosci Rep. 2018; 18: 1-7. https://doi.org/10.1007/s11910-018-0839-1Burkett JG, Ailani J. An up-to-date review of pseudotumor cerebri syndrome. Curr Neurol Neurosci Rep. 2018; 18: 1-7. https://doi.org/10.1007/s11910-018-0839-1Townsend RK, Fargen KM. Intracranial venous hypertension and venous sinus stenting in the modern management of idiopathic intracranial hypertension. Life (Basel). 2021; 11: 508. https://doi.org/10.3390/life11060508Townsend RK, Fargen KM. Intracranial venous hypertension and venous sinus stenting in the modern management of idiopathic intracranial hypertension. Life (Basel). 2021; 11: 508. https://doi.org/10.3390/life11060508Fargen KM, Garner RM, Kittel C, Wolfe SQ. A descriptive study of venous sinus pressures and gradients in patients with idiopathic intracranial hypertension. J Neurointerv Surg. 2020; 12: 320-325. https://doi.org/10.1136/neurintsurg-2019-015251Fargen KM, Garner RM, Kittel C, Wolfe SQ. A descriptive study of venous sinus pressures and gradients in patients with idiopathic intracranial hypertension. J Neurointerv Surg. 2020; 12: 320-325. https://doi.org/10.1136/neurintsurg-2019-015251Fargen KM. Idiopathic intracranial hypertension is not idiopathic: Proposal for a new nomenclature and patient classification. J Neurointerv Surg. 2020; 12: 110-114. https://doi.org/10.1136/neurintsurg-2019-015498Fargen KM. Idiopathic intracranial hypertension is not idiopathic: Proposal for a new nomenclature and patient classification. J Neurointerv Surg. 2020; 12: 110-114. https://doi.org/10.1136/neurintsurg-2019-015498Богомякова ОБ, Валова ГС, Хе АК, Черевко АА. Оценка расстройств гемо- и ликвородинамики при синдроме идиопатической внутричерепной гипертензии по данным МРТ. Комплексные проблемы сердечно-сосудистых заболеваний. 2023; 12(1): 84-93. https://doi.org/10.17802/2306-1278-2023-12-1-84-93Bogomyakova OB, Valova GS, Khe AK, Cherevko AA. Assessment of disorders of hemodynamics and CSF dynamics in idiopathic intracranial hypertension syndrome according to MRI data. Complex Issues of Cardiovascular Diseases. 2023; 12(1): 84-93. (In Russ.). https://doi.org/10.17802/2306-1278-2023-12-1-84-93Elnahry AG, Elnahry GA. Management of idiopathic intracranial hypertension during the COVID-19 pandemic. Rev Recent Clin Trials. 2021; 16(2): 122-125. https://doi.org/10.2174/1574887115666200917111413Elnahry AG, Elnahry GA. Management of idiopathic intracranial hypertension during the COVID-19 pandemic. Rev Recent Clin Trials. 2021; 16(2): 122-125. https://doi.org/10.2174/1574887115666200917111413Ахмадеева ЛР, Гизатуллин РХ, Умутбаев СВ, Гизатуллин РР. Идиопатическая внутричерепная гипертензия или pseudotumor cerebri. Медико-фармацевтический журнал «Пульс». 2019; 21(11): 13-17. https://doi.org/10.26787/nydha-2686-6838-2019-21-11-13-17Akhmadeeva LR, Gizatullin RR, Umutbaev SV, Gizatullin RH. Idiopathic intracranial hypertension or pseudotumor cerebri. Medical & Pharmaceutical Journal “Pulse”. 2019; 21(11): 13-17. (In Russ.). https://doi.org/10.26787/nydha-2686-6838-2019-21-11-13-17Kilgore KP, Lee MS, Leavitt JA, Mokri B, Hodge DO, Frank RD, et al. Re-evaluating the incidence of idiopathic intracranial hypertension in an era of increasing obesity. Ophthalmology. 2017; 124(5): 697-700. https://doi.org/10.1016/j.ophtha.2017.01.006Kilgore KP, Lee MS, Leavitt JA, Mokri B, Hodge DO, Frank RD, et al. Re-evaluating the incidence of idiopathic intracranial hypertension in an era of increasing obesity. Ophthalmology. 2017; 124(5): 697-700. https://doi.org/10.1016/j.ophtha.2017.01.006Gaier ED, Heidary G. Pediatric idiopathic intracranial hypertension. Semin Neurol. 2019; 39(6): 704-710. https://doi.org/10.1055/s-0039-1698743Gaier ED, Heidary G. Pediatric idiopathic intracranial hypertension. Semin Neurol. 2019; 39(6): 704-710. https://doi.org/10.1055/s-0039-1698743Марьенко ИП, Крамаренко АН. Идиопатическая внутричерепная гипертензия: современный взгляд на проблему и трудности ранней диагностики. Неврология и нейрохирургия. Восточная Европа. 2022. 12(2): 186-197. https://doi.org/10.34883/PI.2022.12.2.046Maryenko IP, Kramarenko AN. Idiopathic intracranial hypertension: Actual problem review and early diagnostic problems. Laboratory Diagnostics. Eastern Europe. 2022. 12(2): 186-197. (In Russ.). https://doi.org/10.34883/PI.2022.12.2.046Aylward SC, Waslo CS, Au JN, Tanne E. Manifestations of pediatric intracranial hypertension from the intracranial hypertension registry. Pediatr Neurol. 2016; 61: 76-82. https://doi.org/10.1016/j.pediatrneurol.2016.04.007Aylward SC, Waslo CS, Au JN, Tanne E. Manifestations of pediatric intracranial hypertension from the intracranial hypertension registry. Pediatr Neurol. 2016; 61: 76-82. https://doi.org/10.1016/j.pediatrneurol.2016.04.007Tepe D, Demirel F, Seker ED, Arhan EP, Tayfun M, Esen I, et al. Prevalence of idiopathic intracranial hypertension and associated factors in obese children and adolescents. J Pediatr Endocrinol Metab. 2016; 29(8): 907-914. https://doi.org/10.1515/jpem-2015-0470Tepe D, Demirel F, Seker ED, Arhan EP, Tayfun M, Esen I, et al. Prevalence of idiopathic intracranial hypertension and associated factors in obese children and adolescents. J Pediatr Endocrinol Metab. 2016; 29(8): 907-914. https://doi.org/10.1515/jpem-2015-0470Sheldon CA, Paley GL, Xiao R, Kesler A, Eyal O, Ko MW, et al. Pediatric idiopathic intracranial hypertension: Age, gender, and anthropometric features at diagnosis in a large, retrospective, multisite cohort. Ophthalmology. 2016; 123(11): 2424-2431. https://doi.org/10.1016/j.ophtha.2016.08.004Sheldon CA, Paley GL, Xiao R, Kesler A, Eyal O, Ko MW, et al. Pediatric idiopathic intracranial hypertension: Age, gender, and anthropometric features at diagnosis in a large, retrospective, multisite cohort. Ophthalmology. 2016; 123(11): 2424-2431. https://doi.org/10.1016/j.ophtha.2016.08.004Sheldon CA, Kwon YJ, Liu GT, McCormack SE. An integrated mechanism of pediatric pseudotumor cerebri syndrome: Evidence of bioenergetic and hormonal regulation of cerebrospinal fluid dynamics. Pediatr Res. 2015; 77(2): 282-289. https://doi.org/10.1038/pr.2014.188Sheldon CA, Kwon YJ, Liu GT, McCormack SE. An integrated mechanism of pediatric pseudotumor cerebri syndrome: Evidence of bioenergetic and hormonal regulation of cerebrospinal fluid dynamics. Pediatr Res. 2015; 77(2): 282-289. https://doi.org/10.1038/pr.2014.188Fargen KM, Coffman S, Torosian T, Brinjikji W, Nye BL, Hui F. “Idiopathic” intracranial hypertension: An update from neurointerventional research for clinicians. Cephalalgia. 2023; 43(4): 3331024231161323. https://doi.org/10.1177/03331024231161323Fargen KM, Coffman S, Torosian T, Brinjikji W, Nye BL, Hui F. “Idiopathic” intracranial hypertension: An update from neurointerventional research for clinicians. Cephalalgia. 2023; 43(4): 3331024231161323. https://doi.org/10.1177/03331024231161323Гуляев ДА, Груздев АВ, Петров АА, Чистова ИВ, Курносов ИА, Близнюк ВВ, и др. Случай хирургического лечения пациентки с идиопатической внутричерепной гипертензией. Современные проблемы науки и образования. 2024; (2): 97. https://doi.org/10.17513/spno.33320Gulyaev DA, Gruzdev AV, Petrov AA, Chistova IV, Kurnosov IA, Bliznyuk VV, et al. A case of surgical treatment of a patient with idiopathic intracranial hypertension. Modern Problems of Science and Education. 2024; (2): 97. (In Russ.). https://doi.org/10.17513/spno.33320Крамаренко АН, Марьенко ИП. Прогностические маркеры развития идиопатической внутричерепной гипертензии у пациентов с хронической мигренью. Неврология и нейрохирургия. Восточная Европа. 2025; 15(3): 363-372. https://doi.org/10.34883/PI.2025.15.3.043Kramarenko AN, Maryenko IP. Predictive markers of idiopathic intracranial hypertension in patients with chronic migraine. Neurology and Neurosurgery. Eastern Europe. 2025; 15(3): 363-372. (In Russ.). https://doi.org/10.34883/PI.2025.15.3.043Aylward SC, Aronowitz C, Roach ES. Intracranial hypertension without papilledema in children. J Child Neurol. 2016; 31(2): 177-183. https://doi.org/10.1177/0883073815587029Aylward SC, Aronowitz C, Roach ES. Intracranial hypertension without papilledema in children. J Child Neurol. 2016; 31(2): 177-183. https://doi.org/10.1177/0883073815587029Aylward SC, Aronowitz C, Reem R, Rogers D, Roach ES. Intracranial hypertension without headache in children. J Child Neurol. 2015; 30(6): 703-706. https://doi.org/10.1177/0883073814540522Aylward SC, Aronowitz C, Reem R, Rogers D, Roach ES. Intracranial hypertension without headache in children. J Child Neurol. 2015; 30(6): 703-706. https://doi.org/10.1177/0883073814540522Hartmann AJ, Soares BP, Bruce BB, Saindane AM, Newman NJ, Biousse V, et al. Imaging features of idiopathic intracranial hypertension in children. J Child Neurol. 2017; 32(1): 120-126. https://doi.org/10.1177/0883073816671855Hartmann AJ, Soares BP, Bruce BB, Saindane AM, Newman NJ, Biousse V, et al. Imaging features of idiopathic intracranial hypertension in children. J Child Neurol. 2017; 32(1): 120-126. https://doi.org/10.1177/0883073816671855Ali A, Al-Ani O, Al-Ani F. Children’s behaviour and childhood obesity. Pediatr Endocrinol Diabetes Metab. 2024; 30(3): 148-158. https://doi.org/10.5114/pedm.2024.142586Ali A, Al-Ani O, Al-Ani F. Children’s behaviour and childhood obesity. Pediatr Endocrinol Diabetes Metab. 2024; 30(3): 148-158. https://doi.org/10.5114/pedm.2024.142586Tovia E, Reif S, Oren A, Mitelpunkt A, Fattal-Valevski A. Treatment response in pediatric patients with pseudotumor cerebri syndrome. J Neuroophthalmol. 2017; 37(4): 393-397. https://doi.org/10.1097/WNO.0000000000000516Tovia E, Reif S, Oren A, Mitelpunkt A, Fattal-Valevski A. Treatment response in pediatric patients with pseudotumor cerebri syndrome. J Neuroophthalmol. 2017; 37(4): 393-397. https://doi.org/10.1097/WNO.0000000000000516Jiramongkolchai K, Buckley EG, Bhatti MT, Muh CR, Wiggins RE, Jiramongkolchai P, et al. Temporary lumbar drain as treatment for pediatric fulminant idiopathic intracranial hypertension. J Neuroophthalmol. 2017; 37(2): 126-132. https://doi.org/10.1097/WNO.0000000000000457Jiramongkolchai K, Buckley EG, Bhatti MT, Muh CR, Wiggins RE, Jiramongkolchai P, et al. Temporary lumbar drain as treatment for pediatric fulminant idiopathic intracranial hypertension. J Neuroophthalmol. 2017; 37(2): 126-132. https://doi.org/10.1097/WNO.0000000000000457

The authors declare that there are no conflicts of interest present.